{"id":1018,"date":"2025-04-03T09:43:47","date_gmt":"2025-04-03T01:43:47","guid":{"rendered":"https:\/\/cvd.xin\/?p=1018"},"modified":"2025-04-07T09:40:27","modified_gmt":"2025-04-07T01:40:27","slug":"%e9%a2%84%e9%98%b2%e7%8c%9d%e6%ad%bb-cloned-1008","status":"publish","type":"post","link":"https:\/\/cvd.xin\/?p=1018","title":{"rendered":"\u9152\u7cbe\u4ee3\u8c22\u57fa\u56e0\u4e0e\u4e1c\u4e9a\u4eba\u7fa4\u91cd\u5927\u75be\u75c5\u98ce\u9669\u7684\u5173\u7cfb"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1018\" class=\"elementor elementor-1018\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d325bcd e-flex e-con-boxed e-con e-parent\" data-id=\"d325bcd\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1729e86 elementor-widget elementor-widget-heading\" data-id=\"1729e86\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u9152\u7cbe\u4ee3\u8c22\u57fa\u56e0\u4e0e\u4e1c\u4e9a\u4eba\u7fa4\u91cd\u5927\u75be\u75c5\u98ce\u9669\u7684\u5173\u7cfb<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-47a4328 elementor-widget elementor-widget-post-info\" data-id=\"47a4328\" data-element_type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-b5eae3c elementor-inline-item\" itemprop=\"author\">\n\t\t\t\t\t\t<a href=\"https:\/\/cvd.xin\/?author=1\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-user-circle\" viewBox=\"0 0 496 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M248 104c-53 0-96 43-96 96s43 96 96 96 96-43 96-96-43-96-96-96zm0 144c-26.5 0-48-21.5-48-48s21.5-48 48-48 48 21.5 48 48-21.5 48-48 48zm0-240C111 8 0 119 0 256s111 248 248 248 248-111 248-248S385 8 248 8zm0 448c-49.7 0-95.1-18.3-130.1-48.4 14.9-23 40.4-38.6 69.6-39.5 20.8 6.4 40.6 9.6 60.5 9.6s39.7-3.1 60.5-9.6c29.2 1 54.7 16.5 69.6 39.5-35 30.1-80.4 48.4-130.1 48.4zm162.7-84.1c-24.4-31.4-62.1-51.9-105.1-51.9-10.2 0-26 9.6-57.6 9.6-31.5 0-47.4-9.6-57.6-9.6-42.9 0-80.6 20.5-105.1 51.9C61.9 339.2 48 299.2 48 256c0-110.3 89.7-200 200-200s200 89.7 200 200c0 43.2-13.9 83.2-37.3 115.9z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-author\">\n\t\t\t\t\t\t\t\t\t\tcvd_xin\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-e244842 elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t<a href=\"https:\/\/cvd.xin\/?m=20250403\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-calendar\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M12 192h424c6.6 0 12 5.4 12 12v260c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V204c0-6.6 5.4-12 12-12zm436-44v-36c0-26.5-21.5-48-48-48h-48V12c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v52H160V12c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v52H48C21.5 64 0 85.5 0 112v36c0 6.6 5.4 12 12 12h424c6.6 0 12-5.4 12-12z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>2025-04-03<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a043a5a elementor-widget elementor-widget-text-editor\" data-id=\"a043a5a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u8840\u6db2\u4e2d\u9152\u7cbe\u5206\u89e3\u7684\u4e3b\u8981\u9014\u5f84\u5305\u542b\u4e24\u4e2a\u6b65\u9aa4\uff0c\u9996\u5148\u662f\u5c06\u4e59\u9187\u6c27\u5316\u4e3a\u4e59\u919b\uff0c\u4f9d\u9760\u7684\u662f\u4e59\u9187\u8131\u6c22\u9176\uff08ADH\uff09\uff1b\u7136\u540e\uff0c\u518d\u7531\u4e59\u919b\u8131\u6c22\u9176\uff08ALDH\uff09\uff0c\u4e3b\u8981\u662f<em>ALDH2<\/em>\uff0c\u5c06\u4e59\u919b\u201c\u89e3\u6bd2\u201d\u4e3a\u4e59\u9178<sup>[1]<\/sup>\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-540d979 elementor-widget elementor-widget-image\" data-id=\"540d979\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"580\" height=\"289\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180314-1024x511.png\" class=\"attachment-large size-large wp-image-1022\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180314-1024x511.png 1024w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180314-300x150.png 300w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180314-768x383.png 768w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180314-1200x599.png 1200w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180314.png 1304w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65861f2 elementor-widget elementor-widget-text-editor\" data-id=\"65861f2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u9152\u7cbe\u4ee3\u8c22\u9014\u5f84<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c9e0f3e elementor-widget elementor-widget-text-editor\" data-id=\"c9e0f3e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u4e59\u919b\u662f\u4e00\u79cd\u4e00\u7ea7\u81f4\u764c\u7269\uff0c\u5bf9\u7ec6\u80de\u6bd2\u6027\u5f88\u5927\uff0c\u56e0\u6b64\uff0c\u5982\u679c\u7b2c\u4e00\u6b65\u8fdb\u884c\u7684\u592a\u5feb\uff0c\u53ef\u80fd\u5bfc\u81f4\u9152\u7cbe\u8f6c\u5316\u4e3a\u4e59\u919b\u540e\u7d2f\u79ef\uff0c\u6216\u662f\u7b2c\u4e8c\u6b65\u53d7\u5230\u5f71\u54cd\uff0c\u4e59\u919b\u6e05\u9664\u7684\u5f88\u6162\uff0c\u90fd\u4f1a\u5f71\u54cd\u9152\u7cbe\u4ee3\u8c22\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b9c8d66 elementor-widget elementor-widget-image\" data-id=\"b9c8d66\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"580\" height=\"396\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180815-1024x700.png\" class=\"attachment-large size-large wp-image-1023\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180815-1024x700.png 1024w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180815-300x205.png 300w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180815-768x525.png 768w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180815-1200x821.png 1200w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180815.png 1376w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a31a7fa elementor-widget elementor-widget-text-editor\" data-id=\"a31a7fa\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u4e2d\u56fd\u4eba\u5747\u9152\u7cbe\u6d88\u8d39\u91cf\u57287L\/\u4eba\u5de6\u53f3[2]<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-35143c4 elementor-widget elementor-widget-text-editor\" data-id=\"35143c4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><\/p>\n<p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;\u4e0d\u592a\u5e78\u8fd0\u7684\u662f\uff0c\u4e9a\u6d32\u4eba\uff0c\u5c24\u5176\u662f\u5728\u4e1c\u4e9a\u4eba\u4e2d\uff0c\u4e59\u919b\u8131\u6c22\u9176\uff08ALDH\uff09\u57fa\u56e0<em>ALDH2<\/em>\u643a\u5e26\u7684\u4e00\u4e2a\u5e38\u89c1\u529f\u80fd\u53d8\u5f02<em>ALDH2*2<\/em> (Glu504Lys, rs671)\uff0c\u4f1a\u5bfc\u81f4\u4e59\u919b\u8131\u6c22\u9176\u7684\u6d3b\u6027\u964d\u4f4e\uff0c\u5206\u89e3\u53d8\u6162\uff0c\u4e59\u919b\u5728\u4f53\u5185\u5806\u79ef\u540e\uff0c\u4f1a\u5f15\u8d77\u8840\u7ba1\u6269\u5f20\uff0c\u5bfc\u81f4\u76ae\u80a4\u6f6e\u7ea2\uff0c\u8868\u73b0\u4e3a\u559d\u9152\u4e0a\u8138\uff0c\u5934\u6655\u6076\u5fc3\u7b49\u3002<\/p>\n<p><em><strong>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;ALDH2*2 (<\/strong><\/em><strong>Glu504Lys, rs671)\u662f\u4e1c\u4e9a\u4eba\u559d\u9152\u8138\u7ea2\u4ee5\u53ca\u9152\u91cf\u9650\u5236\u7684\u91cd\u8981\u51b3\u5b9a\u56e0\u7d20\uff0c\u6211\u56fd\u7ea6\u67095\u4ebf\u4eba\u643a\u5e26\u8be5\u529f\u80fd\u53d8\u5f02\u4f4d\u70b9\uff1b<\/strong>\u6b64\u5916\uff0c\u5728\u4e1c\u4e9a\u5e38\u89c1\u7684\u4e59\u9187\u8131\u6c22\u9176\uff08ADH\uff09\u57fa\u56e0<em>ADH1B*2<\/em> (Arg48His, rs1229984)\u7684\u9057\u4f20\u53d8\u5f02\u4f1a\u52a0\u901f\u9152\u7cbe\u8f6c\u5316\u4e3a\u4e59\u919b\uff0c\u8fd9\u4e5f\u662f\u996e\u9152\u7684\u9650\u5236\u6027\u56e0\u7d20\u3002<em>ALDH2*2<\/em> (Glu504Lys, rs671)\u4e0e<em>ADH1B*2 <\/em>(Arg48His, rs1229984)\u8fd9\u4e24\u4e2a\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\u4f4d\u70b9\u52a0\u5728\u4e00\u8d77\u5bf9\u9152\u7cbe\u66b4\u9732\u6709\u5f88\u5927\u5f71\u54cd\uff0c\u5176\u4e2d<em>ALDH2*2<\/em> (Glu504Lys, rs671)\u7684\u5f71\u54cd\u66f4\u5927\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1802dc5 elementor-widget elementor-widget-image\" data-id=\"1802dc5\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"580\" height=\"284\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180819-1024x502.png\" class=\"attachment-large size-large wp-image-1024\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180819-1024x502.png 1024w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180819-300x147.png 300w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180819-768x377.png 768w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180819-1200x588.png 1200w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180819.png 1399w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e46000b elementor-widget elementor-widget-text-editor\" data-id=\"e46000b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<section><p style=\"text-align: center;\"><span style=\"font-size: 12px;\">\u4e1c\u4e9a\u4eba\u9ad8\u9891\u643a\u5e26<em>ALDH2*2<\/em> (Glu504Lys, rs671)\u53d8\u5f02\uff0c\u65e5\u672c\u4eba\u7fa4\u643a\u5e26\u7387\u66f4\u9ad8[3]<\/span><\/p><p style=\"text-indent: 2em;\"><strong>\u9664\u4e86\u6700\u5e38\u89c1\u7684\u9152\u7cbe\u4ee3\u8c22\u5916\uff0c\u7814\u7a76\u8fd8\u53d1\u73b0<em>ALDH2<\/em>\u57fa\u56e0\u7a81\u53d8\u4e0e\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u3001\u764c\u75c7\u7b49\u91cd\u5927\u75be\u75c5\u98ce\u9669\u5347\u9ad8\u3001\u8fc7\u65e9\u8870\u8001\u4ee5\u53ca\u836f\u7269\u4ee3\u8c22\u5f02\u5e38\u76f8\u5173\u3002<\/strong><\/p><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-06c70d5 elementor-widget elementor-widget-text-editor\" data-id=\"06c70d5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<section><p><strong style=\"color: #256975; text-align: justify;\">\u51a0\u5fc3\u75c5<\/strong><\/p><p><span style=\"text-indent: 2em;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u51a0\u5fc3\u75c5\u662f\u7531\u591a\u79cd\u9057\u4f20\u548c\u73af\u5883\u56e0\u7d20\u76f8\u4e92\u4f5c\u7528\u5f15\u8d77\u7684\u590d\u6742\u75be\u75c5\uff0c\u6709\u7814\u7a76\u8868\u660e\uff0c<\/span><em style=\"text-indent: 2em;\">ALDH2*2 <\/em><span style=\"text-indent: 2em;\">\u5bfc\u81f4\u51a0\u5fc3\u75c5\u7684\u98ce\u9669\u589e\u52a0\u4e8648%\u3002\u5185\u76ae\u7ec6\u80de\uff08ECs\uff09\u662f\u8840\u7ba1\u58c1\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u901a\u8fc7\u8c03\u8282\u8840\u7ba1\u5f20\u529b\u548c\u7ed3\u6784\uff0c\u7ef4\u6301\u5fc3\u8840\u7ba1\u7a33\u6001\u8d77\u7740\u5173\u952e\u4f5c\u7528\uff0c\u5185\u76ae\u7ec6\u80de\u529f\u80fd\u969c\u788d\u88ab\u8ba4\u4e3a\u4e0e\u591a\u79cd\u4eba\u7c7b\u5fc3\u8840\u7ba1\u75be\u75c5\u6709\u5173\u3002\u6700\u8fd1\u7684\u7814\u7a76\u53d1\u73b0\uff0c<\/span><em style=\"text-indent: 2em;\">ALDH2*2<\/em><span style=\"text-indent: 2em;\">\u53ef\u589e\u52a0\u8840\u7ba1\u708e\u75c7\uff0c\u8fdb\u800c\u5bfc\u81f4\u5185\u76ae\u7ec6\u80de\u529f\u80fd\u969c\u788d\uff0c\u8fdb\u800c\u589e\u52a0\u51a0\u5fc3\u75c5\u98ce\u9669<\/span><sup style=\"font-size: 11px;\">[4]<\/sup><span style=\"text-indent: 2em;\">\u3002<\/span><\/p><p><strong style=\"text-indent: 2em; color: #256975; text-align: justify;\">\u6d88\u5316\u9053\u80bf\u7624<\/strong><\/p><p><em style=\"text-indent: 2em;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0ALDH2*2<\/em><span style=\"text-indent: 2em;\">\u53ef\u4ee5\u589e\u52a0\u5185\u76ae\u7ec6\u80de\u7684\u6c27\u5316\u5e94\u6fc0\u548c\u708e\u75c7\uff0c\u5bfc\u81f4\u4eba\u4f53\u8840\u7ba1\u529f\u80fd\u53d7\u635f\u5916\uff0c\u4e5f\u4e0e\u6d88\u5316\u9053\u80bf\u7624\u7684\u53d1\u751f\u5bc6\u5207\u76f8\u5173\u3002\u80c3\u764c\u662f\u5168\u7403\u764c\u75c7\u6b7b\u4ea1\u7684\u7b2c\u4e09\u5927\u539f\u56e0\u3002\u80c3\u764c\u53d1\u75c5\u7387\u5728\u5730\u7406\u4e0a\u8868\u73b0\u51fa\u5f3a\u70c8\u7684\u53d8\u5316\uff0c\u5176\u4e2d\u4e1c\u4e9a\u5730\u533a\uff0c\u7279\u522b\u662f\u65e5\u672c\u548c\u97e9\u56fd\u7684\u53d1\u75c5\u7387\u6700\u9ad8\u3002\u4e00\u9879\u5927\u578b\u80c3\u764c\u961f\u5217\u7684\u5168\u5916\u663e\u5b50\u6d4b\u5e8f(WES)\u53d1\u73b0\uff0c70%\u7684\u60a3\u8005\u643a\u5e26<\/span><em style=\"text-indent: 2em;\">ALDH2<\/em><span style=\"text-indent: 2em;\">\u57fa\u56e0\u7a81\u53d8\uff0c\u7ea6\u4e94\u5206\u4e4b\u4e00\u7684\u5f25\u6f2b\u578b\u80c3\u764c\u53ef\u5f52\u56e0\u4e8e\u996e\u9152\u548c\u7f3a\u9677\u7684<\/span><em style=\"text-indent: 2em;\">ALDH2<\/em><span style=\"text-indent: 2em;\">\u7b49\u4f4d\u57fa\u56e0\u6216CDH1\u53d8\u5f02\u7684\u7ec4\u5408<\/span><sup style=\"font-size: 11px;\">[5]<\/sup><span style=\"text-indent: 2em;\">\u3002<\/span><\/p><p><strong style=\"color: #256975; text-align: justify;\">\u8fc7\u65e9\u8870\u8001<\/strong><\/p><p><span style=\"text-indent: 2em;\">\u00a0 \u00a0 \u00a0 \u00a0 \u4e3a\u4e86\u5bf9\u6297\u919b\u7c7b\u7684\u6bd2\u6027\uff0c\u751f\u7269\u4f53\u53d1\u5c55\u4e86\u76f8\u5e94\u7684\u673a\u5236\u6765\u6d88\u9664\u5b83\u4eec\u5e76\u4fee\u590d\u7531\u5176\u5f15\u8d77\u7684\u635f\u4f24\u3002<\/span><em style=\"text-indent: 2em;\">ALDH2<\/em><span style=\"text-indent: 2em;\">\u4e0e<\/span><em style=\"text-indent: 2em;\">ADH5<\/em><span style=\"text-indent: 2em;\">\u57fa\u56e0\u540c\u65f6\u53d8\u5f02\u4f1a\u5bfc\u81f4\u4e00\u79cd\u540d\u4e3aAMeDS\u7efc\u5408\u5f81\u7684\u591a\u7cfb\u7edf\u75be\u75c5\uff0c\u5176\u7279\u5f81\u662f\u7531\u4e8e\u5185\u6e90\u6027\u7532\u919b\u7684\u79ef\u7d2f\u548cDNA\u4fee\u590d\u9014\u5f84\u53d7\u5230\u7532\u919b\u884d\u751f\u7684DNA\u635f\u4f24\u7684\u8d85\u8d1f\u8377\u800c\u5bfc\u81f4\u9aa8\u9ad3\u8870\u7aed\u3001\u667a\u529b\u969c\u788d\u548c\u53d1\u80b2\u7f3a\u9677\u3002\u8fd1\u65e5\uff0c\u6765\u81ea\u65e5\u672c\u540d\u53e4\u5c4b\u5927\u5b66\u7684\u79d1\u7814\u56e2\u961f\u5728Nature Cell Biology\u671f\u520a\u4e0a\u53d1\u8868\u6700\u65b0\u7814\u7a76\u53d1\u73b0<\/span><sup style=\"text-indent: 2em;\">[6]<\/sup><span style=\"text-indent: 2em;\">\uff0c\u919b\u7c7b\u9020\u6210\u7684DNA\u635f\u4f24\u548c\u8fc7\u65e9\u8870\u8001\u4e4b\u95f4\u5b58\u5728\u7d27\u5bc6\u7684\u8054\u7cfb\uff0c\u643a\u5e26<\/span><em style=\"text-indent: 2em;\">Adh5<\/em><span style=\"text-indent: 2em;\">\u548c<\/span><em style=\"text-indent: 2em;\">Aldh2<\/em><span style=\"text-indent: 2em;\">\u529f\u80fd\u4e27\u5931\u7684\u5c0f\u9f20\uff0c\u5176\u5bff\u547d\u660e\u663e\u7f29\u77ed\uff0c\u4f53\u91cd\u51cf\u8f7b\uff0c\u9020\u8840\u529f\u80fd\u5f02\u5e38\u8fd8\u51fa\u73b0\u4e86\u8d2b\u8840\u3002\u4e5f\u5c31\u662f\u8bf4\uff0c\u5bf9\u4e8e\u559d\u9152\u8138\u7ea2\u7684\u4e2a\u4f53\uff0c\u919b\u7c7b\u5728\u4f53\u5185\u7684\u7d2f\u79ef\u5f88\u53ef\u80fd\u52a0\u901f\u8870\u8001\u7684\u53d1\u751f\u3002<\/span><\/p><p><strong style=\"color: #256975; text-align: justify;\">\u836f\u7269\u4ee3\u8c22<\/strong><\/p><p><span style=\"text-align: justify; text-indent: 2em;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u785d\u9178\u7518\u6cb9\u4f5c\u4e3a\u4e00\u79cd\u8840\u7ba1\u6269\u5f20\u5242\uff0c\u88ab\u5e7f\u6cdb\u5730\u5e94\u7528\u4e8e\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u5305\u62ec\u5fc3\u7ede\u75db\u3001\u5fc3\u808c\u6897\u6b7b\u7b49\u3002\u4e1c\u4e9a\u4eba\u7fa4\u4e2d\u643a\u5e26<\/span><em style=\"text-align: justify; text-indent: 2em;\">ALDH2*2<\/em><span style=\"text-align: justify; text-indent: 2em;\">\u7a81\u53d8\u4f4d\u70b9\u7684\u60a3\u8005\u785d\u9178\u7518\u6cb9\u7684\u5fc3\u8840\u7ba1\u4fdd\u62a4\u4f5c\u7528\u66f4\u5f31\uff0c<\/span><em style=\"text-align: justify; text-indent: 2em;\">ALDH2*2<\/em><span style=\"text-align: justify; text-indent: 2em;\">\u5fc3\u7ede\u75db\u60a3\u8005\u7684\u785d\u9178\u7518\u6cb9\u6709\u6548\u7387\u663e\u8457\u4f4e\u4e8e\u91ce\u751f\u578b<\/span><em style=\"text-align: justify; text-indent: 2em;\">ALDH2<\/em><span style=\"text-align: justify; text-indent: 2em;\">\u60a3\u8005\uff0c\u7eaf\u548c\u578b<\/span><em style=\"text-align: justify; text-indent: 2em;\">ALDH2*2<\/em><span style=\"text-align: justify; text-indent: 2em;\">\u6d3b\u6027\u53ea\u6709\u91ce\u751f\u578b\u76845%<\/span><sup style=\"font-size: 11px;\">[7]<\/sup><span style=\"text-align: justify; text-indent: 2em;\">\u3002\u996e\u9152\u9762\u7ea2\u4e5f\u53ef\u80fd\u80fd\u591f\u4f5c\u4e3a\u6c49\u65cf\u51a0\u5fc3\u75c5\u785d\u9178\u7518\u6cb9\u7597\u6548\u9884\u6d4b\u7684\u8868\u5f81\uff0c\u5f53\u7136\uff0c\u76f4\u63a5\u7684\u57fa\u56e0\u68c0\u6d4b\u66f4\u4e3a\u51c6\u786e\u3002<\/span><\/p><\/section>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb0f988 elementor-widget elementor-widget-text-editor\" data-id=\"fb0f988\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: left;\"><strong>\u6653\u82af\u7518<sup>TM<\/sup>\u5fc3\u8111\u8840\u7ba1\u5065\u5eb7\u8bc4\u4f30\u82af\u7247<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-51edca7 elementor-widget elementor-widget-text-editor\" data-id=\"51edca7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;\u4f2f\u79d1\u751f\u7269\u79d1\u6280\u516c\u53f8\u5f00\u53d1\u7684\u5fc3\u8111\u8840\u7ba1\u5065\u5eb7\u8bc4\u4f30\u82af\u7247\uff08 \u6653\u82af\u7518TM\uff09\uff0c\u6db5\u76d6\u4e86528\u4e2a\u57fa\u56e0\uff0c661\u4e2a\u5355\u6838\u82f7\u9178\u591a\u6001\u6027\u4f4d\u70b9\uff08PRS\uff09\uff0c27\u4e2a\u836f\u7269\u57fa\u56e0\u4ee3\u8c22\u4f4d\u70b9\uff1b\u5176\u4e2d\u5305\u542b\u4e86\u5177\u6709\u91cd\u8981\u529f\u80fd\u7684\u4e59\u9187\u8131\u6c22\u9176\u57fa\u56e0\uff08Alcohol &nbsp;dehydrogenases\uff0c\u7b80\u79f0ADH\uff09\u4e0e\u4e59\u919b\u8131\u6c22\u9176\u57fa\u56e0\uff08 Aldehyde &nbsp;dehydrogenase \uff0c\u7b80\u79f0 ALDH\uff09\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; \u6653\u82af\u7518TM\u68c0\u6d4b\u4ee5\u591a\u57fa\u56e0\u9057\u4f20\u98ce\u9669\u4e3a\u57fa\u7840\uff0c\u52a0\u4e0a\u5355\u57fa\u56e0\u81f4\u75c5\u4f4d\u70b9\u7684\u68c0\u6d4b\uff0c\u53ef\u4ee5\u5168\u9762\u8bc4\u4f30\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u7684\u9057\u4f20\u98ce\u9669\uff0c\u5b9e\u73b0\u7cbe\u51c6\u7b5b\u67e5\uff1b\u5229\u7528\u591a\u57fa\u56e0\u9057\u4f20\u98ce\u9669\u548c\u4e34\u5e8a\u98ce\u9669\u7684\u7efc\u5408\u6a21\u578b\u80fd\u591f\u66f4\u52a0\u7cbe\u7ec6\u5316\u7684\u8fdb\u884c\u98ce\u9669\u5206\u5c42\uff1b\u7ed3\u5408\u836f\u7269\u57fa\u56e0\u4ee3\u8c22\u7684\u68c0\u6d4b\uff0c\u9488\u5bf9\u9ad8\u98ce\u9669\u4eba\u7fa4\u8fdb\u884c\u4e2a\u6027\u5316\u5e72\u9884\u4ee5\u53ca\u6709\u6548\u6cbb\u7597\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;\u6653\u82af\u7518TM\u68c0\u6d4b\u5e94\u7528\u7684\u7814\u53d1\u4e0e\u8f6c\u5316\u662f\u57fa\u4e8e\u8fc7\u53bb\u4e8c\u5341\u5e74\u987e\u4e1c\u98ce\u9662\u58eb\u5e26\u9886\u7684\u56fd\u5bb6\u5fc3\u8840\u7ba1\u75c5\u4e2d\u5fc3\u7814\u7a76\u56e2\u961f\u7684\u4e2d\u56fd\u4eba\u7fa4\u5927\u961f\u5217\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76\uff0c\u8fd1\u5341\u591a\u5e74\u7814\u7a76\u56e2\u961f\u534f\u8c03\u7ec4\u7ec7\u4e86\u4e2d\u56fd\u3001\u65b0\u52a0\u5761\u3001\u9a6c\u6765\u897f\u4e9a\u3001\u65e5\u672c\u3001\u83f2\u5f8b\u5bbe\u7b49\u4e1c\u4e9a\u4eba\u7fa4\u4ee5\u53ca\u6b27\u7f8e\u4eba\u7fa4\uff0c\u6d89\u53ca\u5230\u5168\u7403\u8fd1100\u4f59\u4e2a\u961f\u5217\uff0c\u5f00\u5c55\u4e8650\u4e07\u4eba\u7fa4\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u57fa\u56e0\u7ec4\u5b66\u7814\u7a76\uff0c\u7cfb\u7edf\u5730\u89e3\u7801\u4e86\u5f71\u54cd\u4e2d\u56fd\u4eba\u7fa4\u51a0\u5fc3\u75c5\u3001\u8111\u5352\u4e2d\u4ee5\u53ca\u8840\u8102\u5f02\u5e38\u3001\u9ad8\u8840\u538b\u7b49\u4e3b\u8981\u5371\u9669\u56e0\u7d20\u7684\u9057\u4f20\u4fe1\u606f\uff0c\u76f8\u5173\u7814\u7a76\u6210\u679c\u53d1\u8868\u5728Nature Genetics\u3001European Heart Journal\u7b49\u4e16\u754c\u9876\u5c16\u7684\u5b66\u672f\u671f\u520a\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4e29dc2 elementor-widget elementor-widget-image\" data-id=\"4e29dc2\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"580\" height=\"339\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180822-1024x598.png\" class=\"attachment-large size-large wp-image-1025\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180822-1024x598.png 1024w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180822-300x175.png 300w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180822-768x449.png 768w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250402180822.png 1092w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-830a57e elementor-widget elementor-widget-text-editor\" data-id=\"830a57e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u53c2\u8003\u8d44\u6599<\/p><p>1. Millwood I Y, Walters R G, Mei X W, et al. Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China[J]. The Lancet, 2019, 393(10183): 1831-1842.<\/p><p>2. https:\/\/ourworldindata.org\/grapher\/total-alcohol-consumption-per-capita-litres-of-pure-alcohol<\/p><p>3. Chen C H, Ferreira J C B, Mochly-Rosen D. ALDH2 and cardiovascular disease[J]. Aldehyde Dehydrogenases: From Alcohol Metabolism to Human Health and Precision Medicine, 2019: 53-67.<\/p><p>4. Guo H, Yu X, Liu Y, et al. SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant[J]. Science translational medicine, 2023, 15(680): eabp9952.<\/p><p>5. Suzuki A, Katoh H, Komura D, et al. Defined lifestyle and germline factors predispose Asian populations to gastric cancer[J]. Science advances, 2020, 6(19): eaav9778.<\/p><p>6. Oka Y, Nakazawa Y, Shimada M, et al. Endogenous aldehyde-induced DNA\u2013protein crosslinks are resolved by transcription-coupled repair[J]. Nature Cell Biology, 2024: 1-13.<\/p><p>7. Seitz HK, Matsuzaki S, Yokoyama A, Homann N, Vakevainen S,Wang XD. Alcohol and cancer. 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