{"id":1189,"date":"2025-04-03T13:45:13","date_gmt":"2025-04-03T05:45:13","guid":{"rendered":"https:\/\/cvd.xin\/?p=1189"},"modified":"2025-04-07T16:53:02","modified_gmt":"2025-04-07T08:53:02","slug":"%e6%97%a9%e9%98%b2%e3%80%81%e6%97%a9%e6%b2%bb-%e5%86%a0%e5%bf%83%e7%97%85%e5%a4%9a%e5%9f%ba%e5%9b%a0%e9%a3%8e%e9%99%a9%e8%af%84%e4%bc%b0%e6%8c%87%e5%af%bc%e9%9d%92%e5%b9%b4%e7%be%a4%e4%bd%93%e7%9a%84","status":"publish","type":"post","link":"https:\/\/cvd.xin\/?p=1189","title":{"rendered":"\u65e9\u9632\u3001\u65e9\u6cbb-\u51a0\u5fc3\u75c5\u591a\u57fa\u56e0\u98ce\u9669\u8bc4\u4f30\u6307\u5bfc\u9752\u5e74\u7fa4\u4f53\u7684\u964d\u8102\u6cbb\u7597"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1189\" class=\"elementor elementor-1189\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-480e822 e-flex e-con-boxed e-con e-parent\" data-id=\"480e822\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a00fa8d elementor-widget elementor-widget-heading\" data-id=\"a00fa8d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">\u65e9\u9632\u3001\u65e9\u6cbb-\u51a0\u5fc3\u75c5\u591a\u57fa\u56e0\u98ce\u9669\u8bc4\u4f30\u6307\u5bfc\u9752\u5e74\u7fa4\u4f53\u7684\u964d\u8102\u6cbb\u7597<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-618262f elementor-widget elementor-widget-post-info\" data-id=\"618262f\" data-element_type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-0263012 elementor-inline-item\" itemprop=\"author\">\n\t\t\t\t\t\t<a href=\"https:\/\/cvd.xin\/?author=1\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-user-circle\" viewBox=\"0 0 496 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M248 104c-53 0-96 43-96 96s43 96 96 96 96-43 96-96-43-96-96-96zm0 144c-26.5 0-48-21.5-48-48s21.5-48 48-48 48 21.5 48 48-21.5 48-48 48zm0-240C111 8 0 119 0 256s111 248 248 248 248-111 248-248S385 8 248 8zm0 448c-49.7 0-95.1-18.3-130.1-48.4 14.9-23 40.4-38.6 69.6-39.5 20.8 6.4 40.6 9.6 60.5 9.6s39.7-3.1 60.5-9.6c29.2 1 54.7 16.5 69.6 39.5-35 30.1-80.4 48.4-130.1 48.4zm162.7-84.1c-24.4-31.4-62.1-51.9-105.1-51.9-10.2 0-26 9.6-57.6 9.6-31.5 0-47.4-9.6-57.6-9.6-42.9 0-80.6 20.5-105.1 51.9C61.9 339.2 48 299.2 48 256c0-110.3 89.7-200 200-200s200 89.7 200 200c0 43.2-13.9 83.2-37.3 115.9z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-author\">\n\t\t\t\t\t\t\t\t\t\tcvd_xin\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-3567c0a elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t<a href=\"https:\/\/cvd.xin\/?m=20250403\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-calendar\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M12 192h424c6.6 0 12 5.4 12 12v260c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V204c0-6.6 5.4-12 12-12zm436-44v-36c0-26.5-21.5-48-48-48h-48V12c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v52H160V12c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v52H48C21.5 64 0 85.5 0 112v36c0 6.6 5.4 12 12 12h424c6.6 0 12-5.4 12-12z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>2025-04-03<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca1a1a5 elementor-widget elementor-widget-text-editor\" data-id=\"ca1a1a5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;\u968f\u7740\u6211\u56fd\u4eba\u53e3\u8001\u9f84\u5316\u548c\u5fc3\u8111\u8840\u7ba1\u5371\u9669\u56e0\u7d20\u6c34\u5e73\u4e0a\u5347\uff0c\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u7684\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u6301\u7eed\u5347\u9ad8\uff0c\u4ee5\u7f3a\u8840\u6027\u5fc3\u810f\u75c5\u548c\u7f3a\u8840\u6027\u5352\u4e2d\u4e3a\u4e3b\u7684\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\uff08ASCVD\uff09\u6b7b\u4ea1\u7387\u5347\u9ad8\u66f4\u4e3a\u660e\u663e\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u7684\u53d1\u751f\u4e3b\u8981\u662f\u7531\u591a\u79cd\u5371\u9669\u56e0\u7d20\u7684\u957f\u671f\u79ef\u7d2f\u6240\u9020\u6210\u7684\uff0c\u56e0\u6b64\uff0c\u5728\u751f\u547d\u5468\u671f\u65e9\u671f\u7ba1\u63a7\u5371\u9669\u56e0\u7d20\u662f\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u9884\u9632\u7684\u5173\u952e\uff0c\u5f3a\u6709\u529b\u7684\u8bc1\u636e\u5c31\u662f\u901a\u8fc7\u7ba1\u63a7\u5371\u9669\u56e0\u7d20\uff0c\u897f\u65b9\u56fd\u5bb6\u6210\u529f\u7684\u5c06\u5fc3\u8111\u8840\u7ba1\u6b7b\u4ea1\u7387\u964d\u4f4e\u4e8650%\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-409c671 elementor-widget elementor-widget-image\" data-id=\"409c671\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"580\" height=\"82\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250103094740-1024x144.png\" class=\"attachment-large size-large wp-image-1192\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250103094740-1024x144.png 1024w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250103094740-300x42.png 300w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250103094740-768x108.png 768w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250103094740-1200x169.png 1200w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250103094740.png 1359w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-256ceff elementor-widget elementor-widget-text-editor\" data-id=\"256ceff\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0 \u00a0 \u00a0 \u00a0 \u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u4e3b\u8981\u5371\u9669\u56e0\u7d20\u6709\u5438\u70df\u3001\u9ad8\u8840\u538b\u3001\u8840\u8102\u5f02\u5e38\u548c\u7cd6\u5c3f\u75c5\u7b49\u3002<strong>\u77e5\u6653\u81ea\u8eab\u98ce\u9669\uff0c\u5f00\u5c55\u751f\u6d3b\u65b9\u5f0f\u5e72\u9884\u6216\u542f\u52a8\u836f\u7269\u6cbb\u7597\u662f\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u9884\u9632\u7684\u57fa\u672c\u601d\u8def<\/strong>\uff0c\u4f46\u73b0\u6709\u98ce\u9669\u8bc4\u4f30\u6846\u67b6\u53ef\u80fd\u66f4\u9002\u7528\u4e8e\u4e2d\u5e74\u4eba\u548c\u8001\u5e74\u4eba\uff0c\u5728\u9752\u5e74\u4eba\u4e2d\uff0c\u5b83\u4e0d\u8db3\u4ee5\u6307\u5bfc\u9884\u9632\u63aa\u65bd\uff0c\u5bf9\u4e8e\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u8fd9\u79cd\u6162\u6027\u75be\u75c5\uff0c\u5f88\u591a\u5e74\u8f7b\u4eba\u5c06\u957f\u671f\u6301\u7eed\u66b4\u9732\u4e8e\u5371\u9669\u56e0\u7d20\u4e4b\u4e2d\u3002<\/p><p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-size: 1.8rem;\">\u00a0 \u00a0 \u00a0 \u00a0<\/span><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-size: 1.8rem;\">\u00a0<\/span>\u8fd1\u671f\u62a5\u544a\u663e\u793a\u4e2d\u5e74\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u6b7b\u4ea1\u7387\u4e0a\u5347\uff0c\u4ee5\u53ca35-54\u5c81\u5e74\u8f7b\u4eba\u6025\u6027\u5fc3\u808c\u6897\u6b7b\uff08AMI\uff09\u4f4f\u9662\u6bd4\u4f8b\u589e\u52a0\uff0c<strong>\u8fd9\u90fd\u51f8\u663e\u4e86\u4ece\u9752\u5e74\u671f\u5f00\u59cb\u8fdb\u884c\u9884\u9632\u7684\u91cd\u8981\u6027<\/strong>\u3002<\/p><p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-size: 1.8rem;\">\u00a0 \u00a0 \u00a0 \u00a0<\/span><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-size: 1.8rem;\">\u00a0<\/span><strong>\u4e2a\u4f53\u9057\u4f20\u98ce\u9669\u8bc4\u4f30\u80fd\u591f\u5728\u751f\u547d\u65e9\u671f\u8bc6\u522b\u9ad8\u98ce\u9669\u4eba\u7fa4\uff0c\u8fd9\u662f\u52a0\u5f3a\u9752\u5e74\u4eba\u7fa4\u9884\u9632\u7684\u5173\u952e\u624b\u6bb5\u3002<\/strong>\u4e2a\u4f53\u5fc3\u8111\u8840\u7ba1\u9057\u4f20\u98ce\u9669\u5305\u62ec\u4e24\u4e2a\u65b9\u9762\uff0c<strong>\u4e00\u4e2a\u662f\u5355\u57fa\u56e0\u9057\u4f20\u98ce\u9669<\/strong>\uff0c\u4f8b\u5982\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\uff08FH\uff09\uff0c\u5176\u81f4\u75c5\u57fa\u56e0\u5305\u62ecLDLR\u3001APOB\u548cPCSK9\u7b49\uff0c\u5176\u60a3\u75c5\u7387\u7ea6\u4e3a5\u2030\uff0cFH\u60a3\u8005\u4e2d\u8fd120%\u4f1a\u7f79\u60a3\u51a0\u5fc3\u75c5\uff0c\u540c\u65f6\u8fd8\u5177\u6709\u65e9\u53d1\u7279\u5f81\u3002<strong>\u53e6\u4e00\u4e2a\u662f\u591a\u57fa\u56e0\u9057\u4f20\u98ce\u9669<\/strong>\uff0c\u8be5\u9057\u4f20\u98ce\u9669\u662f\u6839\u636e\u901a\u8fc7GWAS\u8bc6\u522b\u7684\u51e0\u5341\u5230\u6570\u5343\u4e2a\u53d8\u5f02\u4f4d\u70b9\u8054\u5408\u8bc4\u4f30\u4e2a\u4f53\u7684\u60a3\u75c5\u98ce\u9669\u30022022\u5e745\u6708\uff0c<strong>\u987e\u4e1c\u98ce\u6559\u6388\u56e2\u961f<\/strong>\u901a\u8fc7\u6574\u5408\u51a0\u5fc3\u75c5\u53ca\u4e3b\u8981\u5371\u9669\u56e0\u7d20\u7684540\u4e2a\u57fa\u56e0\u4fe1\u606f\uff0c<strong>\u6784\u5efa\u4e86\u9002\u7528\u4e8e\u4e2d\u56fd\u4eba\u7fa4\u548c\u4e1c\u4e9a\u4eba\u7fa4\u7684\u51a0\u5fc3\u75c5\u591a\u57fa\u56e0\u98ce\u9669\u8bc4\u5206\uff08PRS\uff09<\/strong>\uff0c\u8be5PRS\u53ef\u4ee5\u6709\u6548\u9884\u6d4b\u51a0\u5fc3\u75c5\u53d1\u75c5\u98ce\u9669\uff0c\u63cf\u7ed8\u4e2a\u4f53\u968f\u5e74\u9f84\u589e\u957f\u7684\u53d1\u75c5\u8f68\u8ff9\uff0c\u5728\u751f\u547d\u65e9\u671f\u4e3a\u51a0\u5fc3\u75c5\u7684\u9ad8\u5371\u4eba\u7fa4\u7b5b\u67e5\u548c\u7cbe\u51c6\u9884\u9632\u63d0\u4f9b\u91cd\u8981\u79d1\u5b66\u8bc1\u636e\u3002<\/p><p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-size: 1.8rem;\">\u00a0 \u00a0 \u00a0 \u00a0<\/span><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-size: 1.8rem;\">\u00a0<\/span>\u63a5\u4e0b\u6765\uff0c\u6211\u4eec\u901a\u8fc7\u4e00\u9879\u7ecf\u5178\u7814\u7a76<sup>[1]<\/sup>\u6765\u4e86\u89e3\u5982\u4f55\u901a\u8fc7\u51a0\u5fc3\u75c5\u591a\u57fa\u56e0\u98ce\u9669\u8bc4\u5206\uff08CAD PRS\uff09\u6307\u5bfc\u9752\u5e74\u7fa4\u4f53\u7684\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u9884\u9632\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-43d62fa elementor-widget elementor-widget-image\" data-id=\"43d62fa\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"580\" height=\"197\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250103094817-1024x347.png\" class=\"attachment-large size-large wp-image-1193\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250103094817-1024x347.png 1024w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250103094817-300x102.png 300w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250103094817-768x260.png 768w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/20250103094817.png 1036w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c9a7f6c elementor-widget elementor-widget-text-editor\" data-id=\"c9a7f6c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: left;\"><span style=\"color: #008080;\"><strong>\u76ee\u7684<\/strong><\/span><\/p>\n<p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">&nbsp; &nbsp; &nbsp; &nbsp;<\/span><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">&nbsp;<\/span>\u5728\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u4e00\u7ea7\u9884\u9632\u4e2d\uff0c\u540c\u65f6\u8003\u8651\u5e74\u9f84\u548c\u4e34\u5e8a\u98ce\u9669\u56e0\u7d20\u7684\u524d\u63d0\u4e0b\uff0c\u63a2\u8ba8CAD PRS\u6307\u5bfc\u5f00\u59cb\u4ed6\u6c40\u7528\u836f\u7684\u4f5c\u7528\u3002<\/p>\n<p style=\"text-align: left;\"><span style=\"color: #008080;\"><strong>\u8bbe\u8ba1\u3001\u8bbe\u7f6e\u548c\u53c2\u4e0e\u8005<\/strong><\/span><\/p>\n<p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">&nbsp; &nbsp; &nbsp; &nbsp;<\/span><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">&nbsp;<\/span>\u8fd9\u662f\u4e00\u9879\u7eb5\u5411\u961f\u5217\u7814\u7a76\uff0c\u62db\u52df\u65f6\u95f4\u4e3a2006\u5e741\u67081\u65e5\u81f32010\u5e7412\u670831\u65e5\uff0c\u6570\u636e\u66f4\u65b0\u81f32021\u5e74\u5e74\u4e2d\uff0c\u4f7f\u7528\u82f1\u56fd\u751f\u7269\u6837\u672c\u5e93\uff08UK Biobank\uff09\u7684\u6570\u636e\u3002\u5728\u65e5\u672c\u751f\u7269\u6837\u672c\u5e93\u8fdb\u884c\u4e86\u590d\u5236\u5206\u6790\u3002\u5206\u6790\u7eb3\u5165\u4e86\u6240\u6709\u6ca1\u6709CAD\u75c5\u53f2\u4e14\u672a\u670d\u7528\u964d\u8102\u6cbb\u7597\u7684\u60a3\u8005\u3002<\/p>\n<p style=\"text-align: left;\"><span style=\"color: #008080;\"><strong>\u66b4\u9732<\/strong><\/span><\/p>\n<p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">&nbsp; &nbsp; &nbsp; &nbsp;<\/span><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">&nbsp;<\/span>CAD PRS\u4f7f\u7528\u5305\u542b241\u4e2a\u5168\u57fa\u56e0\u7ec4\u663e\u8457\u5173\u8054\u7684\u5355\u6838\u82f7\u9178\u53d8\u5f02\uff08SNV\uff09\uff0c\u98ce\u9669\u7b49\u7ea7\u5b9a\u4e49\u4e3a\u4f4e\uff08\u5e95\u90e820%\uff09\u3001\u4e2d\u548c\u9ad8\uff08\u9876\u90e820%\uff09\u3002\u6c47\u603b\u961f\u5217\u65b9\u7a0b\u7528\u4e8e\u4f30\u8ba110\u5e74\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u75c5\uff08ASCVD\uff09\u98ce\u9669\uff0c\u5e76\u5c06\u4e2a\u4f53\u5206\u4e3a\u4f4e\uff08&lt;5%\uff09\uff0c\u4e34\u754c\uff085-&lt;7.5%\uff09\uff0c\u4e2d\u7b49\uff087.5-&lt;20%\uff09\u6216\u9ad8\u98ce\u9669\uff08\u226520%\uff09\u3002<\/p>\n<p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">&nbsp; &nbsp; &nbsp; &nbsp;<\/span><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">&nbsp;<\/span>\u4e3b\u8981\u7ed3\u5c40\u548c\u6d4b\u91cf\u6307\u6807 \u5fc3\u808c\u6897\u6b7b\uff08MI\uff09\u548cASCVD\u4e8b\u4ef6\uff08\u5b9a\u4e49\u4e3a\u4e8b\u4ef6\u6027\u4e34\u5e8aCAD [\u5305\u62ecMI]\u3001\u5352\u4e2d\u6216\u5fc3\u8840\u7ba1\u6b7b\u4ea1\uff09\u3002<\/p>\n<p style=\"text-align: left;\"><strong><span style=\"color: #008080;\">\u7ed3\u679c<\/span><\/strong><\/p>\n<p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">&nbsp; &nbsp; &nbsp; &nbsp;<\/span><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">&nbsp;<\/span>\u5171\u7eb3\u5165\u82f1\u56fd\u751f\u7269\u6837\u672c\u5e93\u7684330 201\u4f8b\u60a3\u8005\uff08\u4e2d\u4f4d\u5e74\u9f8457\u5c81\uff1b57%\u4e3a\u5973\u6027\uff09\u3002\u572810\u5e74\u7684\u968f\u8bbf\u671f\u95f4\uff0c\u67094454\u4eba\u53d1\u751f\u5fc3\u808c\u6897\u6b7b\u3002CAD PRS\u4e0e\u6240\u6709\u5e74\u9f84\u7ec4\u7684\u5fc3\u808c\u6897\u6b7b\u98ce\u9669\u5747\u663e\u8457\u76f8\u5173\uff0c<strong>\u4f46\u5728\u5e74\u8f7b\u5e74\u9f84\u7ec4\u5177\u6709\u66f4\u5f3a\u7684\u98ce\u9669\u9884\u6d4b\u80fd\u529b<\/strong>\uff08\u5e74\u9f84&lt;50\u5c81\uff1aPRS\u6bcf1\u4e2a\u6807\u51c6\u5dee\u7684\u98ce\u9669\u6bd4[HR]\uff0c1.72\uff1b\u5e74\u9f8450-60\u5c81\uff1aHR\uff0c1.46\uff1b\u5e74\u9f84&gt;60\u5c81\uff1aHR\uff0c1.42\uff1bP\u503c&lt;0.001\uff09\u3002<\/p>\n<p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align); font-size: 1.8rem;\">&nbsp; &nbsp; &nbsp; &nbsp; <\/span><strong>\u572850\u5c81\u4ee5\u4e0b\u7684\u60a3\u8005\u4e2d\uff0c\u9ad8PRS\u60a3\u8005\u7684\u5fc3\u808c\u6897\u6b7b\u98ce\u9669\u662f\u4f4ePRS\u60a3\u8005\u76843-4\u500d\u3002<\/strong>\u5728\u65e5\u672c\u751f\u7269\u6837\u672c\u5e93\u4e2d\u590d\u5236\u4e86CAD PRS\u4e0e\u5e74\u9f84\u4e4b\u95f4\u7684\u663e\u8457\u4ea4\u4e92\u4f5c\u7528\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e705bb8 elementor-widget elementor-widget-image\" data-id=\"e705bb8\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"580\" height=\"862\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094827-689x1024.png\" class=\"attachment-large size-large wp-image-1199\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094827-689x1024.png 689w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094827-202x300.png 202w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094827-768x1142.png 768w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094827.png 944w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ed0527 elementor-widget elementor-widget-image\" data-id=\"9ed0527\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"580\" height=\"496\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094831.png\" class=\"attachment-large size-large wp-image-1200\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094831.png 946w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094831-300x257.png 300w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094831-768x657.png 768w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-98dc2d9 elementor-widget elementor-widget-text-editor\" data-id=\"98dc2d9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>&nbsp; &nbsp; &nbsp; &nbsp; \u5f53\u5c06CAD PRS\u6dfb\u52a0\u523050\u5c81\u4ee5\u4e0b\u4e2a\u4f53\u7684\u4e34\u5e8aASCVD\u98ce\u9669\u8bc4\u5206\u65f6<\/strong>\uff0c\u57284373\u4f8b\u4e34\u754c\u98ce\u9669\u60a3\u8005\u4e2d\uff0c\u6709591\u4f8b\uff0820%\uff09\u88ab\u98ce\u9669\u5206\u5c42\u4e3a\u4e2d\u5ea6\u98ce\u9669\uff0c\u9700\u8981\u5f00\u59cb\u670d\u7528\u4ed6\u6c40\u7c7b\u836f\u7269\uff1b\u57287477\u4f8b\u4e34\u754c\u6216\u4e2d\u5ea6\u98ce\u9669\u60a3\u8005\u4e2d\uff0c\u67093198\u4f8b\uff0820%\uff09\u88ab\u5206\u5c42\u4e3a\u4f4e\u98ce\u9669\uff0c\u56e0\u6b64\u4e0d\u9700\u8981\u4ed6\u6c40\u6cbb\u7597\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2625b94 elementor-widget elementor-widget-image\" data-id=\"2625b94\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"580\" height=\"690\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094834-861x1024.png\" class=\"attachment-large size-large wp-image-1201\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094834-861x1024.png 861w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094834-252x300.png 252w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094834-768x913.png 768w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094834-1292x1536.png 1292w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094834-1200x1427.png 1200w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250103094834.png 1296w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-32fc526 elementor-widget elementor-widget-text-editor\" data-id=\"32fc526\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><strong><span style=\"color: #008000;\">\u7ed3\u8bba\u548c\u610f\u4e49<\/span><\/strong><\/p><p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align); font-size: 1.8rem;\">\u00a0 \u00a0 \u00a0 \u00a0 \u00a0<\/span>\u672c\u961f\u5217\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u51a0\u5fc3\u75c5\u591a\u57fa\u56e0\u8bc4\u5206(CAD PRS)\u5728\u5e74\u8f7b\u4e2a\u4f53\u4e2d\u5177\u6709\u66f4\u5f3a\u7684\u9884\u6d4b\u80fd\u529b\uff0c\u53ef\u7528\u4e8e\u66f4\u597d\u5730\u8bc6\u522b\u4e34\u754c\u548c\u4e2d\u5ea6\u4e34\u5e8a\u98ce\u9669\u60a3\u8005\uff0c\u5e76\u4e14\u5e94\u8be5\u5f00\u59cb\u670d\u7528\u4ed6\u6c40\u7c7b\u836f\u7269\u3002<\/p><p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align); font-size: 1.8rem;\">\u00a0 \u00a0 \u00a0 \u00a0 <\/span>\u8be5\u7814\u7a76\u63a2\u8ba8\u4e86CAD PRS\u5728\u4e0d\u540c\u5e74\u9f84\u548c\u4e34\u5e8a\u98ce\u9669\u6c34\u5e73\u4e0a\u7684\u9884\u6d4b\u80fd\u529b\uff0c\u8bc4\u4f30\u4e86<strong>\u591a\u57fa\u56e0\u9057\u4f20\u98ce\u9669<\/strong>\u5bf9\u9752\u5e74\u4eba\u5fc3\u808c\u6897\u6b7b\uff08MI\uff09\u7684\u5f71\u54cd\uff0c\u5e76\u5c06CAD PRS\u4e0e\u5df2\u6709\u7684\u4e34\u5e8a\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6027CVD\uff08ASCVD\uff09\u98ce\u9669\u8bc4\u5206\u7ed3\u5408\u8d77\u6765\uff0c\u4ee5\u66f4\u597d\u7684\u6307\u5bfc\u76ee\u6807\u4eba\u7fa4\u5728\u4e00\u7ea7\u9884\u9632\u4e2d\u7684\u5f00\u59cb\u670d\u7528\u4ed6\u6c40\u7c7b\u836f\u7269\u6cbb\u7597\u3002<\/p><p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align); font-size: 1.8rem;\">\u00a0 \u00a0 \u00a0 \u00a0\u00a0<\/span>\u7814\u7a76\u8005\u6307\u51fa\uff0c\u5bf9\u4e8eASCVD\u4e34\u5e8a\u98ce\u9669\u8f83\u4f4e\u7684\u60a3\u8005\uff0c\u4e0d\u5efa\u8bae\u5c06\u9ad8\u9057\u4f20\u98ce\u9669\u8005\u63d0\u5347\u5230\u9700\u8981\u66f4\u79ef\u6781\u9884\u9632\u63aa\u65bd\u7684\u9ad8\u98ce\u9669\u4eba\u7fa4\u3002\u540c\u6837\uff0c\u5bf9\u4e8e70\u5c81\u4ee5\u4e0a\u7684\u5e74\u957f\u7fa4\u4f53\u548cASCVD\u9ad8\u5371\u60a3\u8005\uff0cCAD PRS\u68c0\u6d4b\u4e0d\u592a\u53ef\u80fd\u6539\u53d8\u4ed6\u6c40\u7c7b\u836f\u7269\u7684\u63a8\u8350\u3002\u4e8b\u5b9e\u4e0a\uff0c\u8003\u8651\u5230\u4ed6\u6c40\u7c7b\u836f\u7269\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u5f88\u597d\uff0c\u4e0d\u5e0c\u671b\u5728\u7b26\u5408\u4e34\u5e8a\u6807\u51c6\u4f46\u9057\u4f20\u98ce\u9669\u4f4e\u7684\u5e74\u8f7b\u4eba\u8eab\u4e0a\u62d2\u7edd\u4f7f\u7528\u5b83\u4eec\uff0c\u56e0\u4e3a\u4ed6\u4eec\u7684\u4e34\u5e8a\u98ce\u9669\u53ef\u80fd\u4f1a\u968f\u7740\u65f6\u95f4\u63a8\u79fb\u800c\u589e\u52a0\uff0c\u5e76\u4e14\u9884\u9632\u52a8\u8109\u786c\u5316\u53ef\u80fd\u5bf9\u4ed6\u4eec\u7684\u957f\u671f\u5065\u5eb7\u6709\u76ca\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-55090fe elementor-widget elementor-widget-text-editor\" data-id=\"55090fe\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #999999;\">\u53c2\u8003\u8d44\u6599<\/span><\/p><p><span style=\"color: #999999;\">1. Marston NA, Pirruccello JP, Melloni GEM, et al. Predictive Utility of a Coronary Artery Disease Polygenic Risk Score in Primary Prevention.\u00a0JAMA Cardiol. 2023;8(2):130-137.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u65e9\u9632\u3001\u65e9\u6cbb-\u51a0\u5fc3\u75c5\u591a\u57fa\u56e0\u98ce\u9669\u8bc4\u4f30\u6307\u5bfc\u9752\u5e74\u7fa4\u4f53\u7684\u964d\u8102\u6cbb\u7597 &nbsp; &nbsp; &nbsp; &nbsp; [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1190,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1189","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/posts\/1189","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cvd.xin\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1189"}],"version-history":[{"count":58,"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/posts\/1189\/revisions"}],"predecessor-version":[{"id":1768,"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/posts\/1189\/revisions\/1768"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/media\/1190"}],"wp:attachment":[{"href":"https:\/\/cvd.xin\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1189"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cvd.xin\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1189"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cvd.xin\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}