{"id":1430,"date":"2025-04-03T18:34:43","date_gmt":"2025-04-03T10:34:43","guid":{"rendered":"https:\/\/cvd.xin\/?p=1430"},"modified":"2025-04-07T16:47:27","modified_gmt":"2025-04-07T08:47:27","slug":"ehj-%e5%88%a9%e7%94%a8%e7%ae%80%e5%8d%95%e4%b9%98%e6%b3%95%e6%a8%a1%e5%9e%8b%ef%bc%8c%e5%b0%86prs%e4%b8%8e%e4%b8%b4%e5%ba%8a%e9%a3%8e%e9%99%a9%e8%af%84%e4%bc%b0%e6%a8%a1%e5%9e%8b%e7%bb%93%e5%90%88","status":"publish","type":"post","link":"https:\/\/cvd.xin\/?p=1430","title":{"rendered":"Neurology|\u4e2d\u56fd\u4eba\u7fa4\u7684\u8111\u5352\u4e2d\u591a\u57fa\u56e0\u9057\u4f20\u98ce\u9669\u8bc4\u5206\u7684\u5f00\u53d1\u548c\u9a8c\u8bc1"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1430\" class=\"elementor elementor-1430\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-480e822 e-flex e-con-boxed e-con e-parent\" data-id=\"480e822\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a00fa8d elementor-widget elementor-widget-heading\" data-id=\"a00fa8d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Neurology|\u4e2d\u56fd\u4eba\u7fa4\u7684\u8111\u5352\u4e2d\u591a\u57fa\u56e0\u9057\u4f20\u98ce\u9669\u8bc4\u5206\u7684\u5f00\u53d1\u548c\u9a8c\u8bc1<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-618262f elementor-widget elementor-widget-post-info\" data-id=\"618262f\" data-element_type=\"widget\" data-widget_type=\"post-info.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-inline-items elementor-icon-list-items elementor-post-info\">\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-0263012 elementor-inline-item\" itemprop=\"author\">\n\t\t\t\t\t\t<a href=\"https:\/\/cvd.xin\/?author=1\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-user-circle\" viewBox=\"0 0 496 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M248 104c-53 0-96 43-96 96s43 96 96 96 96-43 96-96-43-96-96-96zm0 144c-26.5 0-48-21.5-48-48s21.5-48 48-48 48 21.5 48 48-21.5 48-48 48zm0-240C111 8 0 119 0 256s111 248 248 248 248-111 248-248S385 8 248 8zm0 448c-49.7 0-95.1-18.3-130.1-48.4 14.9-23 40.4-38.6 69.6-39.5 20.8 6.4 40.6 9.6 60.5 9.6s39.7-3.1 60.5-9.6c29.2 1 54.7 16.5 69.6 39.5-35 30.1-80.4 48.4-130.1 48.4zm162.7-84.1c-24.4-31.4-62.1-51.9-105.1-51.9-10.2 0-26 9.6-57.6 9.6-31.5 0-47.4-9.6-57.6-9.6-42.9 0-80.6 20.5-105.1 51.9C61.9 339.2 48 299.2 48 256c0-110.3 89.7-200 200-200s200 89.7 200 200c0 43.2-13.9 83.2-37.3 115.9z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-author\">\n\t\t\t\t\t\t\t\t\t\tcvd_xin\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<li class=\"elementor-icon-list-item elementor-repeater-item-3567c0a elementor-inline-item\" itemprop=\"datePublished\">\n\t\t\t\t\t\t<a href=\"https:\/\/cvd.xin\/?m=20250403\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-calendar\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M12 192h424c6.6 0 12 5.4 12 12v260c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V204c0-6.6 5.4-12 12-12zm436-44v-36c0-26.5-21.5-48-48-48h-48V12c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v52H160V12c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v52H48C21.5 64 0 85.5 0 112v36c0 6.6 5.4 12 12 12h424c6.6 0 12-5.4 12-12z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text elementor-post-info__item elementor-post-info__item--type-date\">\n\t\t\t\t\t\t\t\t\t\t<time>2025-04-03<\/time>\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t<\/li>\n\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca1a1a5 elementor-widget elementor-widget-text-editor\" data-id=\"ca1a1a5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #008080;\"><strong>\u7814\u7a76\u80cc\u666f<\/strong><\/span><\/p><p>\u00a0 \u00a0 \u00a0 \u00a0 \u8111\u5352\u4e2d(\u53c8\u79f0\u201c\u4e2d\u98ce\u201d)\u5bfc\u81f4\u7684\u6b7b\u4ea1\u6b63\u5728\u589e\u52a0\u5e76\u5a01\u80c1\u7740\u5168\u4eba\u7c7b\u5065\u5eb7\u3002\u76f8\u6bd4\u4e8e\u897f\u65b9\u56fd\u5bb6\uff0c\u4e2d\u56fd\u4eba\u7fa4\u7684\u8111\u5352\u4e2d\u53d1\u75c5\u7387\u4ee5\u53ca\u51fa\u8840\u6027\u8111\u5352\u4e2d\u5360\u6bd4\u66f4\u9ad8\u3002\u5728\u4e2d\u56fd\uff0c\u8111\u5352\u4e2d\u662f\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u5bfc\u81f4\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\uff0c2017\u5e74\u6b7b\u4ea1\u4eba\u6570\u5df2\u7ecf\u8fbe\u5230207\u4e07\u3002\u8fd1\u671f\u5df2\u6709\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u4e86\u6b27\u6d32\u4eba\u7fa4\u7684\u8111\u5352\u4e2d\u591a\u57fa\u56e0\u9057\u4f20\u98ce\u9669\u8bc4\u5206\u7cfb\u7edf(Polygenic Risk Score\uff0cPRS)\u5e76\u8bc4\u4f30\u4e86\u5176\u5728\u4e34\u5e8a\u5e94\u7528\u7684\u53ef\u884c\u6027<sup>1<\/sup><sup>&#8211;<\/sup><sup>6<\/sup>\uff0c\u800c\u6b27\u6d32\u4eba\u7fa4\u5206\u6790\u6a21\u578b\u5bf9\u4e8e\u4e2d\u56fd\u4eba\u7fa4\u9002\u7528\u7a0b\u5ea6\u5e76\u4e0d\u786e\u5b9a\u3002\u4e2d\u56fd\u76ee\u524d\u5fc3\u8111\u8840\u7ba1\u53d1\u75c5\u98ce\u9669\u7b5b\u67e5\u65b9\u6cd5\u4e3b\u8981\u662f\u57fa\u4e8e\u4f20\u7edf\u7684\u4e34\u5e8a\u5371\u9669\u56e0\u7d20\uff0c\u5982\u9ad8\u8840\u538b\u3001\u7cd6\u5c3f\u75c5\u3001\u8840\u8102\u5f02\u5e38\u7b49\u6307\u6807\uff0c\u4f46\u5728\u5371\u9669\u56e0\u7d20\u51fa\u73b0\u524d\uff0c\u4f20\u7edf\u68c0\u6d4b\u624b\u6bb5\u65e0\u6cd5\u8fdb\u884c\u5fc3\u8111\u8840\u7ba1\u98ce\u9669\u8bc4\u4f30\uff0c\u8bf4\u660e\u4f20\u7edf\u4e34\u5e8a\u68c0\u6d4b\u624b\u6bb5\u5177\u6709\u4e00\u5b9a\u7684\u6ede\u540e\u6027\u3002<\/p><p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">\u00a0 \u00a0 \u00a0 \u00a0<\/span><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">\u00a0<\/span>\u56e0\u6b64\uff0c\u5bf9\u4e2d\u56fd\u4eba\u7fa4\u6784\u5efa\u7279\u6709\u7684\u591a\u57fa\u56e0\u9057\u4f20\u98ce\u9669\u8bc4\u5206(PRS)\u6a21\u578b\u975e\u5e38\u91cd\u8981\u3002\u53e6\u5916\uff0c\u9ad8\u9057\u4f20\u98ce\u9669\u4e2a\u4f53\u7684\u65e9\u671f\u8bc6\u522b\u3001\u5065\u5eb7\u751f\u6d3b\u65b9\u5f0f\u7684\u7ef4\u6301\u4ee5\u53ca\u836f\u7269\u5e72\u9884\u5bf9\u4e2d\u56fd\u53ca\u4e16\u754c\u7684\u8111\u5352\u4e2d\u4e00\u7ea7\u9884\u9632\u6765\u8bf4\u90fd\u662f\u5fc5\u8981\u7684\u3002\u57fa\u4e8e\u4ee5\u4e0a\u80cc\u666f\uff0c<strong>\u56fd\u5bb6\u5fc3\u8840\u7ba1\u75c5\u4e2d\u5fc3\u3001\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u961c\u5916\u533b\u9662\u6d41\u884c\u75c5\u90e8\u3001\u5317\u4eac\u534f\u548c\u533b\u5b66\u9662\u9c81\u5411\u950b\u6559\u6388\u4f5c\u4e3a\u901a\u8baf\u4f5c\u8005\uff0c\u5e76\u4e0e\u725b\u6653\u6b4c\u535a\u58eb\u4e3a\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u4e8e2021\u5e748\u670810\u65e5\u6b63\u5f0f\u53d1\u8868\u4e8e\u300aNeurology\u300b\uff0c\u540d\u4e3a\u201cDevelopment and Validation of a Polygenic Risk Score for Stroke in the Chinese Population\u201d\u7684\u6587\u7ae0\u3002<\/strong>\u8be5\u7814\u7a76\u76ee\u7684\u662f\u6784\u5efa\u9002\u7528\u4e8e\u4e2d\u56fd\u4eba\u7fa4\u7684\u8111\u5352\u4e2d\u591a\u57fa\u56e0\u9057\u4f20\u98ce\u9669\u8bc4\u5206(PRS)\u6a21\u578b\uff0c\u5e76\u5229\u7528\u4e2d\u56fd\u5927\u89c4\u6a21\u524d\u77bb\u6027\u961f\u5217\u4eba\u7fa4\u6570\u636e\u8bc4\u4f30\u8be5\u6a21\u578b\u5728\u8111\u5352\u4e2d\u98ce\u9669\u5206\u5c42\u548c\u4e00\u7ea7\u9884\u9632\u4e2d\u7684\u5e94\u7528\u4ef7\u503c\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-409c671 elementor-widget elementor-widget-image\" data-id=\"409c671\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"580\" height=\"162\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183349-1024x286.png\" class=\"attachment-large size-large wp-image-1431\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183349-1024x286.png 1024w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183349-300x84.png 300w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183349-768x215.png 768w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183349.png 1080w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-256ceff elementor-widget elementor-widget-text-editor\" data-id=\"256ceff\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #008080;\"><strong>\u7ed3\u679c\u5c55\u793a<\/strong><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-452e11b elementor-widget elementor-widget-text-editor\" data-id=\"452e11b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000;\"><strong>1.\u6784\u5efametaPRS\u8bc4\u5206\u6a21\u578b<\/strong><\/span><\/p>\n<p><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">&nbsp; &nbsp; &nbsp; &nbsp;<\/span><span style=\"letter-spacing: -0.27px; color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); font-size: 1.8rem;\">&nbsp;<\/span>\u8111\u5352\u4e2d\u662f\u4e00\u79cd\u7531\u9057\u4f20\u56e0\u7d20\u548c\u73af\u5883\u56e0\u7d20\u5bfc\u81f4\u7684\u590d\u6742\u75be\u75c5\uff0c\u4e0d\u540c\u4eba\u7fa4\u7684\u4e34\u5e8a\u5371\u9669\u56e0\u7d20\u548c\u9057\u4f20\u80cc\u666f\u7684\u5dee\u5f02\u53ef\u80fd\u4f1a\u5f71\u54cd\u8111\u5352\u4e2d\u98ce\u9669\u8bc4\u4f30\u3002\u7814\u7a76\u8005\u5b9a\u4e49\u4e865\u4e2a\u8111\u5352\u4e2d\u4e3b\u8981\u7684\u5371\u9669\u56e0\u7d20(\u5305\u62ec\u9ad8\u8840\u538b\u3001\u8840\u8102\u5f02\u5e38\u3001\u7cd6\u5c3f\u75c5\u3001\u80a5\u80d6\u4ee5\u53ca\u8111\u5352\u4e2d\u5bb6\u65cf\u53f2)\u4ee5\u53ca7\u4e2a\u7406\u60f3\u5fc3\u8111\u8840\u7ba1\u6307\u6807(CVH,cardiovascular health)(\u5982\u672a\u6cbb\u7597\u603b\u80c6\u56fa\u9187TC&lt;200mg\/dl\u7b49)\u3002\u57fa\u4e8e\u5df2\u6709\u7814\u7a76\uff0c\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u5206\u6790(GWAS\uff0cGenome-wide association study)\u5df2\u7ecf\u9274\u5b9a\u4e86\u4e0e\u4e1c\u4e9a\u4eba\u7fa4\u8111\u5352\u4e2d\u76f8\u5173\u768442\u4e2aSNP\u4f4d\u70b9\uff0c\u4ee5\u53ca500\u4f59\u4e2a\u4e0e\u8111\u5352\u4e2d\u76f8\u5173\u8868\u578b(\u8840\u538bBP\u30012\u578b\u7cd6\u5c3f\u75c5T2D\u3001\u8102\u80aa\u3001BMI\u3001\u5fc3\u623f\u98a4\u52a8AF)\u6709\u5173\u7684SNP\u3002\u5229\u75282872\u4e2a\u8111\u5352\u4e2d\u60a3\u8005\u4ee5\u53ca2494\u4e2a\u5bf9\u7167\u4e2a\u4f53\u7684\u57fa\u56e0\u578b\u4fe1\u606f\u4f5c\u4e3a\u8bad\u7ec3\u96c6\uff0c\u5e76\u7ed3\u5408\u5148\u524d\u7814\u7a76\u7684\u57fa\u56e0\u578b\u4fe1\u606f\uff0c\u91c7\u7528logistic\u56de\u5f52\u6a21\u578b\u9009\u62e9\u4e0e\u8111\u5352\u4e2d\u5173\u8054\u6bd4\u503c(odds ratio\uff0cOR)\u6700\u9ad8\u7684\u4e00\u4e2a\u4f5c\u4e3a\u67d0\u4e00\u8868\u578b\u7684PRS\u6a21\u578b\uff0c\u4e00\u5171\u6784\u5efa\u4e8614\u4e2a\u8868\u578b\u7279\u5b9a\u7684PRS\u6a21\u578b(\u8111\u5352\u4e2d\u3001\u51a0\u72b6\u52a8\u8109\u75be\u75c5CAD\u30012\u578b\u7cd6\u5c3f\u75c5T2D\u3001\u5fc3\u623f\u98a4\u52a8AF\u3001\u6536\u7f29\u538bSBP\u3001\u8212\u5f20\u538bDBP\u3001\u5e73\u5747\u52a8\u8109\u538bMAP\u3001\u8109\u538bPP\u3001BMI\u3001\u8170\u56f4WC\u3001\u603b\u80c6\u56fa\u9187TC\u3001\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187LDL-C&nbsp;\u3001\u7518\u6cb9\u4e09\u916fTG\u548c\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\u80c6\u56fa\u9187HDL-C )\u3002\u6700\u540e\u5229\u7528\u5f39\u6027\u7f51\u72b6logistic\u56de\u5f52\u6a21\u578b\u5c06\u8fd914\u4e2a\u8868\u578b\u7684PRS\u6a21\u578b\u6574\u5408\u4e3a\u8111\u5352\u4e2d\u591a\u57fa\u56e0\u9057\u4f20\u98ce\u9669\u7efc\u5408\u8bc4\u5206(metaPRS)\uff0c\u8be5\u6a21\u578b\u5305\u542b534\u4e2aSNP\u4f4d\u70b9\u3002\uff08Figure&nbsp;1\uff09<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-43d62fa elementor-widget elementor-widget-image\" data-id=\"43d62fa\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"558\" height=\"674\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183419.png\" class=\"attachment-large size-large wp-image-1432\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183419.png 558w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183419-248x300.png 248w\" sizes=\"(max-width: 558px) 100vw, 558px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c9a7f6c elementor-widget elementor-widget-text-editor\" data-id=\"c9a7f6c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>&nbsp; &nbsp; &nbsp; &nbsp; \u7814\u7a76\u56e2\u961f\u540c\u65f6\u5229\u752841,006\u4f8b\u4e2d\u56fd\u5927\u89c4\u6a21\u524d\u77bb\u6027\u961f\u5217\u4eba\u7fa4\u7684\u57fa\u56e0\u578b\u4fe1\u606f\u4f5c\u4e3a\u9a8c\u8bc1\u96c6\u5bf9metaPRS\u6a21\u578b\u8fdb\u884c\u9a8c\u8bc1\u3002\u7ecf\u8fc7367,750\u4eba\u5e74\u968f\u8bbf(\u5e73\u5747\u5355\u4e2a\u968f\u8bbf9.0\u5e74)\uff0c1227\u4eba\u572880\u5c81\u53d1\u751f\u4e86\u8111\u5352\u4e2d\u3002\u901a\u8fc7\u9a8c\u8bc1\u96c6\u53d1\u73b0\uff0c\u76f8\u6bd4\u5176\u4ed614\u4e2a\u8868\u578b\u7684PRS\u6a21\u578b\uff0cmetaPRS\u4e0e\u8111\u5352\u4e2d\u7684\u76f8\u5173\u6027\u6700\u663e\u8457(Figure e-6)\u3002\u53e6\u5916\u6240\u6709\u8111\u5352\u4e2d\u3001\u7f3a\u8840\u6027\u5352\u4e2d\u548c\u51fa\u8840\u6027\u5352\u4e2d\u7684\u98ce\u9669\u6bd4(Hazard ratios:HRs)(95% CIs)\u5206\u522b\u4e3a1.28(1.21-1.36)\u30011.29(1.20-1.39)\u548c1.30 (1.17-1.45)\u3002\u7efc\u5408\u4e86\u8111\u5352\u4e2d\u5bb6\u65cf\u53f2\u3001\u9ad8\u8840\u538b\u7b49\u4e3b\u8981\u5371\u9669\u56e0\u7d20\u540e\uff0c\u8111\u5352\u4e2dmetaPRS\u7684HRs\u4ec5\u7565\u5fae\u964d\u4f4e\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e705bb8 elementor-widget elementor-widget-image\" data-id=\"e705bb8\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"580\" height=\"450\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183425.png\" class=\"attachment-large size-large wp-image-1433\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183425.png 800w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183425-300x233.png 300w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183425-768x596.png 768w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1dd0331 elementor-widget elementor-widget-text-editor\" data-id=\"1dd0331\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: left;\"><span style=\"color: #000000;\"><strong>2.\u5229\u7528\u9a8c\u8bc1\u96c6\u6570\u636e\u9884\u6d4b\u8111\u5352\u4e2d\u9057\u4f20\u7ec8\u751f\u98ce\u9669<\/strong><\/span><\/p><p>\u00a0 \u00a0 \u00a0 \u00a0 \u7814\u7a76\u56e2\u961f\u901a\u8fc7metaPRS\u8bc4\u5206\u663e\u8457\u7684\u4e94\u5206\u4f4d\u70b9\u68af\u5ea6\u5bf9\u8111\u5352\u4e2d\u98ce\u9669\u8fdb\u884c\u5206\u5c42(\u4f4e\u53710-20%\u3001\u4e2d\u537120%-80%\u3001\u9ad8\u537180-100%)\uff0c\u5206\u5c42\u540e\u53d1\u73b0\u9ad8\u5371\u9057\u4f20\u98ce\u9669\u4e2a\u4f53\u53d1\u751f\u8111\u5352\u4e2d\u7684\u98ce\u9669\u6bd4(HRs)\u662f\u4f4e\u5371\u9057\u4f20\u98ce\u9669\u4e2a\u4f53\u76842\u500d\u5de6\u53f3\uff0c\u4e14\u8111\u5352\u4e2d\u7ec8\u751f\u98ce\u9669\u4e5f\u63a5\u8fd12\u500d(Figure 2)\uff0c\u9ad8\u3001\u4f4e\u5371\u9057\u4f20\u98ce\u9669\u4e2a\u4f53\u8111\u5352\u4e2d\u7ec8\u751f\u98ce\u9669\u5206\u522b\u4e3a\uff1a25.2%(95% CI: 22.5%-27.7%)\uff0c13.6%(95% CI: 11.6%-15.5%)\u3002\u53e6\u5916\uff0c5\u79cd\u4e3b\u8981\u5371\u9669\u56e0\u7d20\u4e5f\u88ab\u8bc1\u660e\u4e0e\u8111\u5352\u4e2d\u4e8b\u4ef6\u663e\u8457\u76f8\u5173\u3002\u7efc\u5408\u9057\u4f20\u56e0\u7d20\u548c\u8111\u5352\u4e2d\u5bb6\u65cf\u53f2\u8003\u8651\uff0c\u5728\u4f4e\u5371\u9057\u4f20\u98ce\u9669\u5e76\u65e0\u8111\u5352\u4e2d\u5bb6\u65cf\u53f2\u7684\u4e2a\u4f53\u4e2d\uff0c\u8111\u5352\u4e2d\u7ec8\u751f\u98ce\u9669\u4e3a13.2% (95% CI: 11.1%-15.1%)\u3002\u76f8\u53cd\u5730\uff0c\u9ad8\u5371\u9057\u4f20\u98ce\u9669\u5e76\u5177\u6709\u8111\u5352\u4e2d\u5bb6\u65cf\u53f2\u7684\u4e2a\u4f53\uff0c\u8111\u5352\u4e2d\u7ec8\u751f\u98ce\u9669\u9ad8\u8fbe41.1%(95% CI: 31.4%-49.5%)(Figure 3)\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ed0527 elementor-widget elementor-widget-image\" data-id=\"9ed0527\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"430\" height=\"524\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183431.png\" class=\"attachment-large size-large wp-image-1434\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183431.png 430w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183431-246x300.png 246w\" sizes=\"(max-width: 430px) 100vw, 430px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2625b94 elementor-widget elementor-widget-image\" data-id=\"2625b94\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"428\" height=\"479\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183437.png\" class=\"attachment-large size-large wp-image-1435\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183437.png 428w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183437-268x300.png 268w\" sizes=\"(max-width: 428px) 100vw, 428px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-98dc2d9 elementor-widget elementor-widget-text-editor\" data-id=\"98dc2d9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000;\"><strong>&nbsp;3.\u7ef4\u6301\u7406\u60f3CVH\u6307\u6807\u80fd\u591f\u62b5\u6d88\u9ad8\u5371\u9057\u4f20\u98ce\u9669 &nbsp; &nbsp; &nbsp;<\/strong><\/span><\/p>\n<p>&nbsp; &nbsp; &nbsp; &nbsp; \u6700\u540e\u7814\u7a76\u56e2\u961f\u8fd8\u8c03\u67e5\u4e86\u901a\u8fc7\u7ef4\u6301\u5355\u4e2a\u6216\u8005\u7ed3\u5408\u591a\u4e2a\u7406\u60f3\u7684\u5fc3\u8840\u7ba1\u5065\u5eb7\u6307\u6807CVH\u80fd\u591f\u5f88\u5927\u7a0b\u5ea6\u4e0a\u964d\u4f4e\u9ad8\u5371\u9057\u4f20\u7684\u7ec8\u751f\u98ce\u9669\u3002\u5728<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">7<\/span>\u4e2a<span style=\"font-family: arial, helvetica, sans-serif;\">CVH<\/span>\u6307\u6807\u4e2d\uff0c\u7406\u60f3\u7684\u8840\u538b(<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">HRs 0.39 95% CIs:0.33-0.46<\/span>)\u548c\u7a7a\u8179\u8840\u7cd6(<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">HRs 0.67 95% CIs:0.59-0.75<\/span>)\u4e0e\u8111\u5352\u4e2d\u5747\u6709\u663e\u8457\u76f8\u5173\u6027\uff0c\u5e76\u4e14\u8fd9\u4e24\u4e2a\u6307\u6807\u5728\u4f4e\u5371\u3001\u4e2d\u5371\u3001\u9ad8\u5371\u9057\u4f20\u98ce\u9669\u5206\u5c42\u4e2d\uff0c\u964d\u4f4e\u8111\u5352\u4e2d\u7ec8\u751f\u98ce\u9669\u6548\u679c\u6700\u597d(<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">Figure&nbsp;4<\/span>)\uff0c\u5373\u6709\u663e\u8457\u7684\u7edd\u5bf9\u5371\u9669\u5ea6\u964d\u4f4e(<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">Absolute Risk Reduction, ARR<\/span>)\u3002\u53e6\u5916\u7ed3\u5408\u591a\u4e2a\u7406\u60f3<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">CVH<\/span>\u8bc4\u4f30\u8111\u5352\u4e2d\u7ec8\u751f\u98ce\u9669\u964d\u4f4e\u6548\u679c\uff0c\u5f53\u4e2a\u4f53\u5177\u6709\u9ad8\u5371\u9057\u4f20\u98ce\u9669\u65f6\uff0c\u62e5\u6709\u826f\u597d\u7684<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">CVH<\/span>\u6307\u6807(<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">6-7<\/span>\u4e2a\u5065\u5eb7\u6307\u6807)\u7684\u8111\u5352\u4e2d\u7ec8\u751f\u98ce\u9669\u6bd4\u62e5\u6709\u4e0d\u826f<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">CVH<\/span>\u6307\u6807(<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">0-3<\/span>\u4e2a\u5065\u5eb7\u6307\u6807)\u7684\u8111\u5352\u4e2d\u7ec8\u751f\u98ce\u9669\u964d\u4f4e\u4e86<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">21.4%<\/span>(<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">Figure&nbsp;5<\/span>)\u3002\u53c8\u76f8\u8f83\u4e8e\u4f4e\u5371\u9057\u4f20\u98ce\u9669\u4e2a\u4f53\u6765\u8bf4\uff0c\u9ad8\u5371\u9057\u4f20\u98ce\u9669\u4e2a\u4f53\u7531\u4e8e\u7406\u60f3CVH\u6307\u6807\u7684\u7ef4\u6301\u7ec8\u751f\u98ce\u9669\u7684\u7edd\u5bf9\u5371\u9669\u5ea6\u964d\u4f4e(<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">ARR<\/span>)\u662f\u4f4e\u5371\u7684<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">1.8<\/span>\u500d\u5de6\u53f3\uff0c\u8bf4\u660e\u9ad8\u5371\u9057\u4f20\u98ce\u9669\u4e2a\u4f53\u63a7\u5236<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">CVH<\/span>\u6307\u6807\uff0c\u6536\u83b7\u7684\u6548\u679c\u6bd4\u4f4e\u5371\u9057\u4f20\u98ce\u9669\u4e2a\u4f53\u66f4\u4e3a\u660e\u663e(<span style=\"font-family: \u5fae\u8f6f\u96c5\u9ed1, 'Microsoft YaHei';\">Figure&nbsp;5<\/span>)\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dbebea6 elementor-widget elementor-widget-image\" data-id=\"dbebea6\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"580\" height=\"534\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183442.png\" class=\"attachment-large size-large wp-image-1436\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183442.png 844w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183442-300x276.png 300w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183442-768x707.png 768w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-47d9fd0 elementor-widget elementor-widget-image\" data-id=\"47d9fd0\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"580\" height=\"293\" src=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183450.png\" class=\"attachment-large size-large wp-image-1437\" alt=\"\" srcset=\"https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183450.png 836w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183450-300x151.png 300w, https:\/\/cvd.xin\/wp-content\/uploads\/2025\/04\/\u5fae\u4fe1\u56fe\u7247_20250403183450-768x388.png 768w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-32fc526 elementor-widget elementor-widget-text-editor\" data-id=\"32fc526\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><span style=\"color: #008080;\"><strong>\u7ed3\u679c\u548c\u7ed3\u8bba<\/strong><\/span><\/p>\n<p>&nbsp; &nbsp; &nbsp; &nbsp; \u7814\u7a76\u56e2\u961f\u57fa\u4e8e\u4e2d\u56fd\u5927\u89c4\u6a21\u524d\u77bb\u6027\u961f\u5217\u4eba\u7fa4\u5f00\u53d1\u4e86metaPRS\u6a21\u578b\uff0c\u5e76\u7ed3\u5408\u4e3b\u8981\u4e34\u5e8a\u5371\u9669\u56e0\u7d20\u548c\u5fc3\u8840\u7ba1\u5065\u5eb7\u6307\u6807CVH\u5bf9\u8111\u5352\u4e2d\u98ce\u9669\u9884\u6d4b\u6027\u80fd\u8fdb\u884c\u4e86\u8bc4\u4f30\u3002metaPRS\u5355\u72ec\u6216\u4e0e\u4e3b\u8981\u4e34\u5e8a\u5371\u9669\u56e0\u7d20\u76f8\u7ed3\u5408\u80fd\u591f\u5c06\u4e2a\u4f53\u7684\u8111\u5352\u4e2d\u7ec8\u751f\u98ce\u9669\u5206\u5c42\u3002\u6b64\u5916\uff0c\u9ad8\u5371\u9057\u4f20\u98ce\u9669\u4e2a\u4f53\u7ef4\u6301\u7406\u60f3\u7684CVH\u6307\u6807\u76f8\u8f83\u4e8e\u4f4e\u5371\u4e2a\u4f53\u80fd\u591f\u66f4\u663e\u8457\u5730\u964d\u4f4e\u53d1\u751f\u8111\u5352\u4e2d\u7684\u98ce\u9669\u3002<\/p>\n<p>&nbsp; &nbsp; &nbsp; &nbsp; \u8be5\u7814\u7a76\u6784\u5efa\u4e86metaPRS\u591a\u57fa\u56e0\u9057\u4f20\u98ce\u9669\u7efc\u5408\u8bc4\u5206\u65b9\u6cd5\u5e76\u80fd\u5bf9\u4e2a\u4f53\u53d1\u751f\u8111\u5352\u4e2d\u7684\u9057\u4f20\u53d1\u75c5\u98ce\u9669\u8fdb\u884c\u5206\u5c42\uff0c\u5e76\u5728\u751f\u547d\u65e9\u671f\u7b5b\u67e5\u51fa\u9057\u4f20\u98ce\u9669\u8f83\u9ad8\u7684\u4eba\u7fa4\u3002<strong>metaPRS<\/strong><strong>\u8bc4\u5206\u6a21\u578b\u5c06\u6709\u52a9\u4e8e\u5f00\u5c55\u8111\u5352\u4e2d\u65e9\u671f\u98ce\u9669\u9884\u6d4b\uff0c\u5e76\u5efa\u8bae\u9ad8\u5371\u4eba\u7fa4\u8fdb\u884c\u4e2a\u6027\u5316\u836f\u7269\u5e72\u9884\u548c\u751f\u6d3b\u65b9\u5f0f\u6539\u5584\uff0c\u4ece\u800c\u964d\u4f4e\u8111\u5352\u4e2d\u6b7b\u4ea1\u7387\uff0c\u5bf9\u8111\u5352\u4e2d\u4e00\u7ea7\u9884\u9632\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-55090fe elementor-widget elementor-widget-text-editor\" data-id=\"55090fe\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #999999;\">\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p><p><span style=\"color: #999999;\">1. Ibrahim-Verbaas CA, Fornage M, Bis JC, et al. Predicting stroke through genetic risk functions: the CHARGE Risk\u00a0Score Project. Stroke 2014;45:403-412.<\/span><\/p><p><span style=\"color: #999999;\">2. Malik R, Bevan S, Nalls MA, et al. Multilocus genetic risk score associates with ischemic stroke in case-control and\u00a0prospective cohort studies. Stroke 2014;45:394-402.<\/span><\/p><p><span style=\"color: #999999;\">3. Tada H, Shiffman D, Smith JG, et al. Twelve-single nucleotide polymorphism genetic risk score identifies\u00a0individuals at increased risk for future atrial fibrillation and stroke. Stroke 2014;45:2856-2862.<\/span><\/p><p><span style=\"color: #999999;\">4. Rutten-Jacobs LC, Larsson SC, Malik R, et al. Genetic risk, incident stroke, and the benefits of adhering to a\u00a0healthy lifestyle: cohort study of 306 473 UK Biobank participants. BMJ 2018;363:k4168.<\/span><\/p><p><span style=\"color: #999999;\">5. Abraham G, Malik R, Yonova-Doing E, et al. Genomic risk score offers predictive performance comparable to\u00a0clinical risk factors for ischaemic stroke. Nat Commun 2019;10:5819.<\/span><\/p><p><span style=\"color: #999999;\">6. Said MA, Verweij N, van der Harst P. Associations of Combined Genetic and Lifestyle Risks With Incident\u00a0Cardiovascular Disease and Diabetes in the UK Biobank Study. JAMA cardiology 2018;3:693-702.<\/span><\/p><p>\u539f\u6587\u94fe\u63a5\uff1a<\/p><p>https:\/\/n.neurology.org\/content\/97\/6\/e619<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Neurology|\u4e2d\u56fd\u4eba\u7fa4\u7684\u8111\u5352\u4e2d\u591a\u57fa\u56e0\u9057\u4f20\u98ce\u9669\u8bc4\u5206\u7684\u5f00\u53d1\u548c\u9a8c\u8bc1 \u7814\u7a76\u80cc\u666f \u00a0 \u00a0 \u00a0 \u00a0 \u8111\u5352\u4e2d(\u53c8\u79f0\u201c\u4e2d [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1445,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1430","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-8"],"_links":{"self":[{"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/posts\/1430","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cvd.xin\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1430"}],"version-history":[{"count":31,"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/posts\/1430\/revisions"}],"predecessor-version":[{"id":1747,"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/posts\/1430\/revisions\/1747"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cvd.xin\/index.php?rest_route=\/wp\/v2\/media\/1445"}],"wp:attachment":[{"href":"https:\/\/cvd.xin\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1430"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cvd.xin\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1430"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cvd.xin\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1430"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}